publications

2024

1. Sci. Adv.

   Increased genomic instability and reshaping of tissue microenvironment underlie oncogenic properties of Arid1a mutations

   A. D’Ambrosio, D. Bressan, and E. Ferracci

   Science Advances Mar 2024

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   Oncogenic mutations accumulating in many chromatin-associated proteins have been identified in different tumor types. With a mutation rate from 10 to 57%, ARID1A has been widely considered a tumor suppressor gene. However, whether this role is mainly due to its transcriptional-related activities or its ability to preserve genome integrity is still a matter of intense debate. Here, we show that ARID1A is largely dispensable for preserving enhancer-dependent transcriptional regulation, being ARID1B sufficient and required to compensate for ARID1A loss. We provide in vivo evidence that ARID1A is mainly required to preserve genomic integrity in adult tissues. ARID1A loss primarily results in DNA damage accumulation, interferon type I response activation, and chronic inflammation leading to tumor formation. Our data suggest that in healthy tissues, the increased genomic instability that follows ARID1A mutations and the selective pressure imposed by the microenvironment might result in the emergence of aggressive, possibly immune-resistant, tumors.

   @article{paperArid1a,
     title = {Increased genomic instability and reshaping of tissue microenvironment underlie oncogenic properties of Arid1a mutations},
     author = {D'Ambrosio, A. and Bressan, D. and Ferracci, E.},
     journal = {Science Advances},
     volume = {10},
     issue = {11},
     pages = {eadh4435},
     numpages = {0},
     year = {2024},
     month = mar,
     publisher = {American Association for the Advancement of Science,},
     doi = {10.1126/sciadv.adh4435},
     url = {https://www.science.org/doi/10.1126/sciadv.adh4435},
     altmetric = {160788191},
     dimensions = {true},
     google_scholar_id = {u-x6o8ySG0sC},
   }

2023

1. Oral Talk

   Increased genomic instability and reshaping of tissue microenvironment drive ARID1A-dependent cancer formation

   D. Bressan

   SIBBM 2023. Frontiers in Molecular Biology - Bari, IT Jun 2023

2022

1. Poster

   The role of mSWI/SNF complex in preserving liver tissue homeostasis and preventing hepatocellular carcinoma formation

   D. Bressan, A D’Ambrosio, and E. Ferracci

   PEZCOLLER SYMPOSIUM - Trento, IT Jun 2022
2. Poster

   Role of the mSWI/SNF chromatin remodeling complex in preserving liver homeostasis

   D. Bressan, A D’Ambrosio, and E. Ferracci

   EACR - Seville, SP Jun 2022